Instructions

MUTATION:SELECTION BALANCE. Genetic diseases arise from the segregation of deleterious alleles. These are usually recessive, but in rare cases they are co-dominant or dominant Consider a hypothetical genetic variant, “a”, which researchers find is associated with reduced survival compared to individuals with the wildtype “A” allele. Assume for the questions below that the per generation mutation rate that creates this deleterious allele is 10* (approximately correct for single locus). Assume also that the population of the world is 7,000,000,000 (a, 3pts) If this genetic disorder is recessive and the equilibrium Fitness = % frequency of the deleterious allele is q=0.001825, what is the relative fitness of homozygous sufferers of this disorder? (express this as a percentage of the wildtype fitness and provide your answer to 3 significant figures) qu # sick (b, 3pts) What is the expected equilibrium number of sick people in the world? (express this as an integer) # carriers (c, 3pts) In this population, what is your best estimate of the number of individuals who are “carriers”, heterozygotes, for this disorder? (express this as an integer) f(a) (d, 3 pts) If the deleterious allele were dominant instead, what would the expected frequency of the allele be in the population? (provide your answer to 3 significant figures) # sick (e, 3 pts) If the deleterious allele were dominant instead, what would the predicted number of individuals with this disorder in the population be? (express this as an integer) 70-6 х 1001825 =

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