Which of the following protein domains interacts with a co-receptor expressed by cytotoxic T-cells? A. The beta 3 domain of MHC class I molecules B. The alpha 2 domain of MHC class II molecules C. The alpha 3 domain of MHC class I molecules D. The beta 1 domain of MHC class II molecules E. The alpha 1 domain of MHC class I molecules 2. Which of the following molecules interacts with beta2 microglobulin? A. MHC class II molecules B. HLA-DM C. CDI D. Invariant chain E. A and C are correct 3. A function of CD4 is to: A. Act as a co-receptor for interactions between a helper T-cell and an antigen presenting cell B. Present glycolipid antigens to T-cells C. Stabilize the interaction between the membrane bound immunoglobulin and an MHC molecule D. Contribute to helper T-cell activation after recognition of antigen presented by MHC class I E. A and C are correct 4. How many different MHC class II molecules would be expressed by a single T-lymphocyte from an outbred heterozygous mouse. A.O B. 2 C.3 D. 6 E. 12 5. Place the following events in the correct sequence for MHC class I molecules on an epithelial cell. 1. association of ERp57 with the MHC molecule 2. binding of the antigen into the binding cleft 3. dissociation of calreticulin from the MHC molecule 4. binding of beta2 microglobulin to the MHC molecule 5. association of calnexin with the MHC molecule A.5,3,4,1,2 B. 1,4,5,2,3 C. 5,4,1,2,3 D. 1,2,4,5,3 E. 5, 1,2,4,3 6. Which of the following cell types can process antigen via the cytosolic pathway? A. Macrophages B. Red blood cells C. T-lymphocytes D. A and C are correct E. A, B, and C are correct 7. Which antigen processing pathway can a B-lymphocyte use to present antigen to a CD8+ T-cell? A. cytosolic B. endotoxic C. endocytic D. myeloid E. lymphoid 8. Which of the following is NOT mediated by products of the MHC? A. Presentation of non-protein antigens by dendritic cells B. Presentation of protein antigens to T-lymphocytes C. Recognition of protein antigens by B-lymphocytes D. Transport of antigenic peptides across the endoplasmic reticulum membrane E. A and Care correct 9. LMP gene products: A. Present antigen peptides to the T-cell receptor B. Modify the function of the proteasome C. Catalyze the removal of the CLIP D. Act as molecular chaperones E. Stabilize the interaction between the T-cell and the APC 10. Which of the following accurately describes a difference between a membrane-bound immunoglobulin and a T-cell receptor? A. The T-cell receptor has a single polypeptide chain that is embedded in the plasma membrane while membrane-bound immunoglobulin has two. B. A T-cell receptor has a higher avidity than a membrane-bound immunoglobulin. C. Membrane-bound immunoglobulin contains domains with an immunoglobulin fold structure while the T-cell receptor does not D. Membrane-bound immunoglobulin is made up of two polypeptide chains while the T-cell receptor is composed of four polypeptide chains. E. The T-cell receptor is likely to have a higher dissociation constant for antigen binding. 11. Why do T-cell receptors show more diversity than immunoglobulin molecules in developing lymphocytes in the primary lymphoid organs? A. TOT adds nucleotides in both chains B. Junctional flexibility in both chains C. Alternative D gene segment joining D.P-region nucleotide addition in both chains E. A and Care correct 12. Which of the following can be explained by the fact that the MHC haplotypes are co-dominantly expressed? A. The F1 progeny of two different inbred homozygous mouse strains cannot accept tissue from either parent. B. Inbred animal populations show increased susceptibility to disease. C. Two different inbred homozygous mouse strain parents cannot accept tissue from their Fl progeny, D. Fixed macrophages cannot elicit antigen-specific T-cell activation. E. A and Care correct. 13. Which of the following molecules is NOT involved in an interaction between a helper T-cell and an antigen presenting cell? A. CDS B.B7 C. An exogenous peptide antigen D. A self MHC class Il molecule E A and Care correct 14. In an outbred mouse population how many different genetic combinations are theoretically possible in the MHC? A. 2 B. 6 C. 8 D. 14 E. A trillion 15. Which of the following statements regarding the T-cell receptor is correct? A. A CD4+ T-cell shows self class I MHC restriction B. A T-cell receptor demonstrates promiscuous antigen binding C. Each individual T-cell recognizes a specific antigen epitope D. A B-cell can only recognize an antigen presented with non-self MHC molecules E. A and Care correct 16. The CDRs on a single T-cell receptor on a helper T-cell interact with which of the following: A. A self MHC class II molecule B. An external hydrophilic antigen epitope C. A specific antigen epitope D. CDS E. A and Care correct 17. An epithelial cell would be expected to be able to process and present which of the following? A. An endogenous protein antigen B. An exogenous non-protein antigen C. An exogenous protein antigen D. A and Care correct E. A, B and Care correct 18. Which of the following best describes the molecule that is responsible for the presentation of a non-protein antigen to a CD4+ T-cell. A. It is a dimer of two polypeptides that are both encoded by genes within the MHC B. It is composed of two heterodimers and one homodimer that contain immunoglobulin fold domains C. It is a homodimer of polypeptide chains and has one protein antigen binding site D. It is a heterodimer of polypeptides that have a constant domain and a hypervariable region E. It is a dimer of two polypeptides neither of which are encoded by genes within the MHC 19. Which of the following is NOT expressed on the surface of a cytotoxic T-cell? A. MHC class I molecules B. T-cell receptor C. B7 D. CD3 E. A and C are correct 20. Which of the following contributes to diversity in T-cell receptor beta chains but NOT immunoglobulin light chains? A. N-region nucleotide addition B. P-region nucleotide addition C. Alternative D gene segment joining D. Junctional flexibility E. A and C are correct

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