What are the functions of the signal recognition particle (SRP) and translocon in protein transport to the ER? SRP Translocon B. How does the translocon determine which orientation to insert membrane proteins? C How do budding & bsion aflec thirolin n tnspor D. Consider a ligand-gated ion channel at the plasma membrane that binds to ligands in the cytoplasm. From a hydropathy plot, you determine the protein has the following general structural elements: 5 Trans-membrane domains (boxes 1-5) Flanking charges around the first transmembrane domain (+and) 6 soluble domains (wavy lines A-F) Your colleague states that either region B or E contains the ligand binding domain, but is unsure which. Which region is more likely to contain the ligand-binding domain? Please explain your reasoning.

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