Which of the following statements best explains why cation concentration impacts the stability of double stranded DNA?

1.Increasing [cation] changes the colligative properties of the solution.

2. Increasing [cation] disrupts the hydrogen bonds.

3.Increasing [cation] enhances the solvation of the nucleic acid.

4.Increasing [cation] minimizes the electrostatic repulsions within the nucleic acid backbones.

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