The rate limiting enzyme of heme biosynthesis is ALA synthase. In hepatocytes, it is repressed by high levels of: succinyl COA iron heme glycine QUESTION 68 Leptin and adiponectin are two hormones released by fat tissues which regulate the body fat homeostasis. Which of the following statement is correct? Leptin increases when fat mass increases, which inhibits food intake as a negative physiological feedback Both inhibits the catabolism of fat. Both stimulates the catabolism of fat. Adiponection releases following fat mass increases, which stimulates food intake as a positive physiological feedback QUESTION 67 The potential causes of elevated levels of bilirubin or its derivatives in blood (hyperbilirubinemia) include the following. EXCEPT for: genetic defects of ALA synthase Liver failure, such as hepatitis (inflammation of liver) or liver cancer. hemolytic: eg: increased breakdown of red blood cells obstruction of bile duct caused by gallstone, inflammation, tumor or other pathological changes QUESTION 66 The molecule Glutathione is: a methyl group donor in methylation reactions a tripeptide of glutamate, cysteine and glycine protecting cells from oxidative stress an enzyme involved in the biosynthesis of glutamate a byproduct of glutamate catabolism

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