Instructions

Problem 5. Effects of Acid-Base Equilibria on Drug Absorption and Elimination. Aspirin (acetylsalicylic acid) is a weak acid with pKA- 3.5. As regimen of aspirin that results in a stable concentration of the uncharged acid form (HA) of the drug that is equal to 10-5 M in the stomach (pH 3.0), the plasma (pH-7.4), and the urine (pH 8.0 sume that a patient is administered a dosing Problem 5A (6 points). Use the Henderson-Hasselbach Equation (8) shown below to calculate the molar concentration of the charged anionic base form of aspirin (A-) that is present in the stomach, plasma and urine (2 points each). [HA] Problem 5B (3 points). Use your results above to calculate the ratio of the concentration of the anion base form (A-) of aspirin for Urine/Plasma, Plasma Stomach, and Urine/Stomach (1 points each). Problem 5C (1 point). For a patient admitted to the emergency room for aspirin overdose, how should urine pH be adjusted to favor the rapid elimination of aspirin?

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