Instructions

Robin Holliday proposed a brilliant theory explaining how homologous recombination can occur without ever introducing double-strand breaks: break one strand in each DNA, accomplish branch migration, resolve the Holliday structure by breaking and reconnecting the other two strands. Turns out that this was neither correct, nor necessary. Rather, homologous recombination starts with a double-strand break in one of the chromatids 2.1. Which DNA repair mechanisms are capable of repairing double strand breaks? 2.2. Using the above text as a template fill in blanks in a short assay about Francis Crick and adapter molecule theory. (This would have been a very difficult problem in an “everything closed” exam. It is quite simple on an “everything open one. You must cite your sources if you use external sources! No need to cite lectures, note, textbook, etc.) Francis Crick proposed a brilliant theory explaining how can occur namely how the correct becomes paired with the that encodes it. Namely, he proposed that there must be an adaptor molecule, which and suggested the as the adapter molecule. Turns out that everything is more complicated. While indeed is complementary to the there is no chemical match between any part of its structure and the amino acid. Rather the match between and the amino acid is accomplished by “a secondary adaptor”, namely by

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