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what are the examples and definitions of bottom up processes & top down processes

When DNA gyrase was isolated, its activity was assessed by gel electrophoresis (shown below).  Relaxed DNA was shown to become increasingly supercoiled over time until all of the relaxed DNA at the top of the gel would run at the bottom of the gel.  If the pattern of bands generated by DNA gyrase was compared to the pattern of a type I topoisomerase, how would they differ?

Explain the difference between natural selection, artificial selection and genetic modification

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