Instructions

The ‘hygiene hypothesis’ has been proposed as an explanation for the rapid increase in allergies and asthma incidence in Western countries over the last half century. One line of evidence supporting this hypothesis is:

a. Individuals that are infected with Hepatitis A virus are more likely to develop allergies and asthma.

b. Individuals that are infected with RSV as infants are protected from developing allergies and asthma later in life.

c. Individuals living in Western countries have fewer CD4 Treg cells in their mucosal tissues.

d. Individuals of African descent have much higher incidence of atopic disease when living in Western countries.

e. Persistent exposure with helminthic parasites predisposes individuals to developing atopic diseases due to increased Type II immune responses.

2.The response of most individuals to contact with poison ivy includes the development of redness, swelling, blistering (edema fluid accumulation between the dermis and the epidermis), and itching. If one intended to transfer this response from a sensitized to a naive individual, one would transfer:

a. Mast cells with their pre-bound IgE from the sensitized to the naive individual

b. T cells from the skin-draining lymph nodes of the sensitized to the naive individual

c. Fcg-receptor positive phagocytes from the skin of the sensitized to the naive individual

d. Dendritic cells from the skin of the sensitized to the naive individual

e. Purified IgG antibody from the serum of the sensitized to the naive individual

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