In human glutamate-mediated synaptic transmission, glutamate (molecular weight 146 g/mol) is released into the synaptic cleft from vesicles with a diameter of 70 nm. If there are 5 000 transmitter molecules in each vesicle, calculate the change in entropy caused by the glutamate release of one synaptic vesicle (consider only the fraction produced by glutamate). Model the synaptic gap with a disk-like volume 50 nm thick and 1m in diameter. Ignore all factors related to glutamate binding. The body temperature is 37°C.

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