Instructions

Which of the following is a mechanism by which the opening of chromatin can spread?

a) Histones phosphorylate neighboring histones through histone kinases

b) Acetylation of histones causes DNA to wind more tightly around these histones, and therefore unwind in other regions of the chromatin

c) Acetylation of histones marks them for degradation, causing the DNA wrapped around them to become unwound

d) Acetylated histones serve as binding sites for histone acetylating enzymes to act on neighboring histones

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