A hemoglobin with an abnormal electrophoretic mobility is detected in a screening program. Fingerprinting after tryptic digestion reveals that the amino acid substitution is in the b chain. The normal amino-terminal tryptic (digested with trypsin) peptide (Val-His-Leu-Thr-Pro-Glu-Glu-Lys) is missing. A new tryptic peptide consisting of six amino acid residues is found. Valine is the amino terminal residue of this peptide. a. Which amino acid substitutions are consistent with these data? b. Which single base changes in DNA sequence could give these amino acid substitutions? The DNA sequence encoding the normal amino terminal region is GTGCACCTGACTCCT GAGGAGAAG. c. How should the electrophoretic mobility of the abnormal hemoglobin compare with those of HD A at pH 8 (would it move quicker or slower to the anode)?

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