Instructions

Why are individuals who are heterozygous for a mutated tumor-suppressor gene at greater risk of developing cancer?

 Only heterozygous people develop cancer
 If a person is heterozygous they are NOT at greater risk of developing cancer.
 Loss of heterozygosity and haploinsufficiency can both lead to the tumor-suppressor gene no longer carrying out its normal regulatory role and these situations are more likely to affect a person who is already short a “good copy”.
 Tumor-suppressor genes are dominant-acting so a heterozygous person will definitely develop cancer.

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