Instructions

1. Cells in a tumor contain mutated copies of a particular gene, which results in tumor growth promotion. Gene therapy can be used to introduce a normal copy of this gene into the tumor cells. Would you expect this therapy to be effective if the mutated gene were an oncogene? A tumor-suppressor gene? Explain your reasoning

2. Explain how altering methylation (adding or removing) of tumor suppressor and proto-oncogenes could be used for treatment of cancer.

3. Compare and contrast familial with sporadic retinoblastoma

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