why is it genetically unfavorable for a vesicle to fuse with a random membrane that it encounters?

my guess is this:

The vesicle and membrane have a hydrophilic shell around them and H2O is coating the membranes and in order to get close enough to fuse, the water must get kicked off. That is energetically unfavorable because those are highly polar interactions, so it takes energy to remove the H2O coating that is present on the vesicle and target plasma membrane.

please help because i have no idea.

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