How might a knowledge of the structure of an active site of an enzyme allow you to build a drug to regulate a metabolic pathway? 2. Cystic fibrosis is a genetic disorder that results in a defective membrane transport protein. The defective protein closes chloride ion channels in membranes, preventing chloride ions from being exported out of cells. This results in the development of a thick mucus on the outer surfaces of cells. This mucus clogs the ducts that carry digestive enzymes from the pancreas to the small intestine, clogs the airways in the lungs, and promotes lung infections. Why do you think the defective protein results in a thick, sticky mucus outside the cells, instead of a loose, fluid covering? 3. Some prokaryotes, especially archaea, are capable of living in extreme environments, such as deep-sea vents, where temperatures can reach 80°C (176°F). Few organisms can survive at this temperature. What adaptations might archaea possess that allow them to survive in such extreme heat?

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