Instructions

One target of such “negative eugenics” miaht have been Wilson disease (OMIM 2779001 an autosomal recessive disorder in which a defect in copper transport results in tremo slurred speech, and behavioral abnormalities. Wilson disease is rare, occurring in one about 30 million people. 1. Based on its incidence, calculate the frequency of the recessive allele responsible for Wilson disease. Calculate the proportion of heterozygous carriers of Wilson disease. What is the ratio of heterozygotes to homozygous recessives? Imagine that all people with Wilson disease are kept from reproducing for 100 years. Assuming random mating and a generation time of 20 years, calculate the frequency of the recessive allele responsible for Wilson disease at the end of the 100 years of selection. Calculate the incidence of Wilson disease at the end of the 100 years of selection. Express your answer as the number of affected people per million. Based on your calculations, combined with everything you’ve learned in this lab explain why such negative eugenic measures would be ineffective 142 GENETICS LAS MANUAL y Part Three-Selection and Eugenics son disease is an autosomal recessive andar that occurs in about 30 per m on people calculate the frequency of the recessive allele responsible for Wilson disease. 2 Calculate the proportion of heterozygous carriers of Wilson disease and the ratio of het- rozygotes to homozygous recessives. 3. If no one with Wilson disease is allowed to reproduce for 100 years, what will the fre- quency of the recessive allele responsible for Wilson disease be? (Assume random mating and a generation time of 20 years.) Calculate the incidence of Wilson disease at the end of the 100 years of selection. Express your answer as the number of affected people per million. But on your lations, combined with everything you’ve learned in this lab. explain why such negative eugenic measures would be ineffective.

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