Instructions

Describe the experimental paradigm for understanding memory and learning in a mammal: LTP in the hippocampus.

2.       Demonstrate how, at the receptor level, LTP requires simultaneous activation of presynaptic and postsynaptic neurons (i.e., Hebbian learning).

Describe how a modification of the expression of a subunit of NMDA receptors (Doogie) can result in a major change in behavior, namely spatial learning.

2.       List types of changes (short and long-term) associated with synaptic plasticity.

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