Instructions

Our cells have a multitude of different transport proteins on their surface. But not all cells have identical transporters, or they don’t have some transporters at all. What transport proteins a cell expresses depends on the cell’s functions. For example, only excitable cells, neurons, muscle, and endocrine glands express voltage-gated sodium and potassium channels. Other cells simply do not have them. They don’t need them, and nature is very stingy with producing what it does not use. This assignment is an example of the variety of glucose transporters that are present in selected cells in the body. Different organs express different types of glucose transporters that allow them to differently partake in glucose supplied by the blood. For example, nervous tissue has preferred access to glucose, when the concentration of glucose is low in the blood. Yet another glucose transporter is needed in barrier cells to make sure that the glucose that enters from the gut does not escape back through the uniporter. Remember, some tissues express multiple types of glucose transporters, that allow them to differently accept glucose in different metabolic states such as pre- and postprandial (before and after the meal). For each of the cell types or tissues below, list ALL of the glucose transporters they express i.e. specific GLUTS, SGLT1. glucose supplied by the blood. For example, nervous tissue has preferred access to glucose, when the concentration of glucose is low in the blood. Yet another glucose transporter is needed in barrier cells to make sure that the glucose that enters from the gut does not escape back through the uniporter. Remember, some tissues express multiple types of glucose transporters, that allow them to differently accept glucose in different metabolic states such as pre- and postprandial (before and after the meal). For each of the cell types or tissues below, list ALL of the glucose transporters they express i.e. specific GLUTS, SGLT1. This excel has a drop-down menu for the transporters. Use it please to avoid confusion. Glucose transporters.xlsx_ Please think from multiple angles, about diverse transporters classes, and different types of GLUTS such as GLUT1, GLUT 2, GLUT 3, and GLUT 4. Leave the box empty if there are fewer transporters in the cell than the boxes. Please do not put more transport proteins that the cell has. Hint: GLUT 1 is ubiquitous and present in ALMOST all cells, with few exceptions. Check any genetic databases for different GLUT expression. Cell/Tissue Glucose Transporters Second Third First cardiac muscle skeletal muscle intestinal epithelium neurons liver cells bone cells pancreatibc beta cells

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