What are the functionally distinct domains (regions) of antibody and TCR molecules? What features of the amino acid sequences in these regions are important for their functions? What are the differences in the types of antigens recognized by antibodies and TCRs? What mechanisms contribute to the diversity of antibody and TCR molecules? Which of these mechanisms contributes the most to the diversity? What are some of checkpoints during lymphocyte maturation that ensure survival of the useful cells? What is the phenomenon of negative selection, and what is its importance?

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