The sickle-cell anemia allele encodes an abnormal hemoglobin protein that gives red blood cells a characteristic “sickle” shape. The wild-type allele encodes normal hemoglobin. Individuals homozygous for the sickle-cell allele suffer from sickle-cell anemia disease (low blood oxygen), while heterozygous and homozygous wild-type individuals do not suffer from the disease. There may be a benefit to the sickle cell allele because a single copy of this allele makes people resistant to malaria. Even though the sickle-cell allele encodes an abnormal protein, the sound of protein expressed from the mutant allele is about the same as the amount of protein expressed front the wild-type allele.

The disease sickle-cell anemia is

  1. Incompletely dominant
  2. Epistatic
  3. Recessive
  4. Co-dominant 
  5. Dominant 

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