Aspirin (acetylsalicylic acid, ASA) is a weak acid with a pKa of 3.5. In the stomach, where the pH is 2.0, it is protonated and uncharged (nonpolar). Inside the epithelial cells of the stomach lining, the pH is 7.1. In this pH environment ASA becomes unprotonated and charged (ASA-). What might the consequence of the stomach pH be on the passive diffusion of ASA?
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