Posttranslational regulation is a key component of many gene product control. The p53 protein is a great example of this. Explain the regulation of this gene’s protein levels and localization due to post translational modifications. (include a description of what the modifications do, don’t just say it is phosphorylated for example, but what does this do to the protein’s function) 10) 10pts Outline the Wnt Signaling pathway’s off and on states. Include the role following proteins or functions and explain what might be the consequences of a mutation in each. (Wnt, Frizzled, LRP, APC, Axin, Dsh, GSK3-B, phosphorylation) 11) 4pts Describe what kind of cancer related gene APC is from the above pathway and describe why you think this is true.

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